| Primary Identifier | MGI:97798 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 19225 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables several functions, including heme binding activity; prostaglandin-endoperoxide synthase activity; and protein homodimerization activity. Involved in several processes, including brown fat cell differentiation; cellular response to non-ionic osmotic stress; and regulation of inflammatory response. Acts upstream of or within several processes, including cyclooxygenase pathway; decidualization; and response to nematode. Located in cytoplasm; neuron projection; and nuclear membrane. Is active in endoplasmic reticulum lumen. Is expressed in several structures, including early embryo; extraembryonic component; genitourinary system; limb long bone; and skin. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); avian influenza; cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2). PHENOTYPE: Homozygous null mice exhibit increased perinatal mortality associated with frequent lack of closure and remodeling of the ductus arteriosus, background-sensitive kidney dysplasia with microcyst formation, and myocardial fibrosis. Mutant females show impaired fertility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
