| Primary Identifier | MGI:2152389 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 117198 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in immunodeficiency 70. Orthologous to human IVNS1ABP (influenza virus NS1A binding protein). PHENOTYPE: Mice homozygous for a knock-out allele exhibit some early lethality, increased cellular sensitivity to cytochalasin and doxorubicin, and doxorubicin-induced cardiotoxicity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
