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Protein Coding Gene : Rnasel ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)

Primary Identifier  MGI:1098272 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  24014
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables ribonucleoprotein complex binding activity. Acts upstream of or within fat cell differentiation; positive regulation of D-glucose import; and regulation of mRNA stability. Predicted to be located in nuclear matrix. Is expressed in several structures, including brain and retina nuclear layer. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate cancer. Orthologous to human RNASEL (ribonuclease L).
PHENOTYPE: Mice homozygous for disruptions in this gene have an enlarged spleen and increased succeptibility to viral infection. [provided by MGI curators]
  • synonyms:
  • ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent),
  • MGI:2445191,
  • E230029I04Rik,
  • 2-5A-dependent RNAase,
  • RIKEN cDNA E230029I04 gene,
  • Rnasel

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

6 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For