Primary Identifier | MGI:1098272 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 24014 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ribonucleoprotein complex binding activity. Acts upstream of or within fat cell differentiation; positive regulation of D-glucose import; and regulation of mRNA stability. Predicted to be located in nuclear matrix. Is expressed in several structures, including brain and retina nuclear layer. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate cancer. Orthologous to human RNASEL (ribonuclease L). PHENOTYPE: Mice homozygous for disruptions in this gene have an enlarged spleen and increased succeptibility to viral infection. [provided by MGI curators] |