| Primary Identifier | MGI:87860 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 11352 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables magnesium ion binding activity; manganese ion binding activity; and protein tyrosine kinase activity. Involved in several processes, including positive regulation of T cell migration; positive regulation of establishment of T cell polarity; and synapse maturation. Acts upstream of or within several processes, including T cell differentiation; nervous system development; and regulation of signal transduction. Located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including brain; diaphragm; hemolymphoid system gland; hindlimb long bone; and seminiferous cord. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene display multiple behavioral abnormalities indicating neuronal defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
