| First Author | Kruh GD | Year | 1986 |
| Journal | Science | Volume | 234 |
| Issue | 4783 | Pages | 1545-8 |
| PubMed ID | 3787260 | Mgi Jnum | J:8517 |
| Mgi Id | MGI:56983 | Doi | 10.1126/science.3787260 |
| Citation | Kruh GD, et al. (1986) A novel human gene closely related to the abl proto-oncogene. Science 234(4783):1545-8 |
| abstractText | A DNA sequence related to the abl proto-oncogene was identified in human placenta. Molecular cloning and nucleotide sequence analysis revealed two putative exons whose predicted amino acid sequence was most homologous to the corresponding sequences of c-abl and v-abl but was related to other tyrosine kinase genes as well. The new sequence was localized by in situ hybridization and somatic cell genetic analysis to human chromosome 1q24-25, which differs from the location of any previously identified tyrosine kinase gene. The detection of a novel 12-kb transcript by this gene in human normal and tumor cells establishes it as a new member of the tyrosine kinase family that is closely related to but distinct from c-abl. |
