Primary Identifier | MGI:99516 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 21960 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable integrin binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of neuron projection development; and regulation of cell migration. Acts upstream of or within several processes, including locomotory exploration behavior; modulation of chemical synaptic transmission; and negative regulation of axon extension involved in regeneration. Located in cell surface; membrane raft; and perineuronal net. Part of tenascin complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including aorta tunica media; brain; heart; urinary system; and ventral grey horn. Orthologous to human TNR (tenascin R). PHENOTYPE: In spite of having decreased conduction velocity in the optic nerve and ultrastrucural alterations within the hippocampus, homozygous null mice are viable, fertile, and display normal behavior. [provided by MGI curators] |