Primary Identifier | MGI:2673064 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 240873 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; regulation of T cell activation; and regulation of leukocyte chemotaxis. Located in cell surface. Is expressed in skin; submandibular gland; and thyroid gland. Orthologous to human TNFSF18 (TNF superfamily member 18). PHENOTYPE: Liver progenitor cell-specific conditional knock-out mice show attenuated ductular reaction, liver inflammation and liver fibrosis upon liver injury induced by feeding a choline-deficient diet supplemented with ethionine. [provided by MGI curators] |