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Protein Coding Gene : Tnfsf18 tumor necrosis factor (ligand) superfamily, member 18

Primary Identifier  MGI:2673064 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  240873
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; regulation of T cell activation; and regulation of leukocyte chemotaxis. Located in cell surface. Is expressed in skin; submandibular gland; and thyroid gland. Orthologous to human TNFSF18 (TNF superfamily member 18).
PHENOTYPE: Liver progenitor cell-specific conditional knock-out mice show attenuated ductular reaction, liver inflammation and liver fibrosis upon liver injury induced by feeding a choline-deficient diet supplemented with ethionine. [provided by MGI curators]
  • synonyms:
  • tumor necrosis factor (ligand) superfamily, member 18,
  • Tnfsf18,
  • Gitrl,
  • GITR ligand

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

4 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For