| Primary Identifier | MGI:2138346 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 226551 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in positive regulation of collagen biosynthetic process; positive regulation of osteoblast differentiation; and regulation of bone remodeling. Located in membrane and rough endoplasmic reticulum. Is expressed in several structures, including gut; hemolymphoid system gland; liver; lung; and musculoskeletal system. Used to study osteogenesis imperfecta type 5. Orthologous to human SUCO (SUN domain containing ossification factor). PHENOTYPE: Mice homozygous for a mutation in this gene display background strain-dependent neonatal and postnatal lethality, and impaired osteoblast differentiation resulting in impaired bone formation, brittle bones, and impaired fracture repair. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
