Primary Identifier | MGI:2676890 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 387210 |
Mgi Type | miRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including cellular response to forskolin; cellular response to mechanical stimulus; and negative regulation of metabolic process. Is expressed in several structures, including alimentary system; limb bud; neural tube; nose; and skeletal muscle tissue. Orthologous to human MIR214 (microRNA 214). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased myocyte apoptosis, fibrosis and myocyte size following cardiac ischemia and reperfusion with altered calcium transients in cardiomyocytes. [provided by MGI curators] |