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Protein Coding Gene : Ccdc181 coiled-coil domain containing 181
Primary Identifier  MGI:1922145 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  74895
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables microtubule binding activity. Located in manchette and sperm flagellum. Is expressed in 3rd ventricle; 4th ventricle; and choroid invagination. Orthologous to human CCDC181 (coiled-coil domain containing 181).
PHENOTYPE: Homozygous null males are infertile, with defective late spermatids that undergo apoptosis and lead to a decline in sperm counts. Sperm show defective head shaping, acrosome detachment, impaired manchette formation, and defects in sperm flagellum and motility. [provided by MGI curators]
  • synonyms:
  • coiled-coil domain containing 181,
  • RIKEN cDNA 4930455F23 gene,
  • AI427889,
  • expressed sequence AI427889,
  • MGI:2138234,
  • Ccdc181,
  • 4930455F23Rik
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2 Involved In Mutations

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