| Primary Identifier | MGI:88108 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 11931 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ATPase activator activity and protein kinase binding activity. Involved in several processes, including monoatomic cation transmembrane transport; protein stabilization; and regulation of cardiac muscle contraction by calcium ion signaling. Acts upstream of or within blastocyst development. Located in several cellular components, including basolateral plasma membrane; intercalated disc; and sarcolemma. Part of sodium:potassium-exchanging ATPase complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart and pericardium; and respiratory system. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human ATP1B1 (ATPase Na+/K+ transporting subunit beta 1). PHENOTYPE: Mice homozygous for a conditional allele activated in cardiac tissue exhibit age-related cardiac hypertrophy and reduced cardiac function, insensitivity to ouabain, and increased heart dysfunction following aortic constriction. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
