| Primary Identifier | MGI:1344382 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 433375 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable insulin-like growth factor receptor binding activity. Acts upstream of or within several processes, including endocytosis; lysosomal lumen acidification; and regulation of DNA-templated transcription. Located in endosome and lysosome. Part of transcription regulator complex. Is expressed in central nervous system; liver; and ureter. Orthologous to human CREG1 (cellular repressor of E1A stimulated genes 1). PHENOTYPE: Mice heterozygous for a knock-out allele exhibit decreased neovascularization after induction of hindlimb ischemia, and show increased infarction size, elevated cardiomyocyte apoptosis and impaired autophagy following myocardial ischemia/reperfusion injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
