| Primary Identifier | MGI:2138453 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 98558 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable sequence-specific DNA binding activity. Involved in piRNA processing and transposable element silencing by piRNA-mediated DNA methylation. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; meiotic nuclear division; and negative regulation of macromolecule biosynthetic process. Located in several cellular components, including chromosome; cytoplasmic ribonucleoprotein granule; and male germ cell nucleus. Is expressed in brain; early conceptus; and genitourinary system. Orthologous to human MAEL (maelstrom spermatogenic transposon silencer). PHENOTYPE: Male mice homozygous for a null allele are infertile and display small testes, a complete block of spermatogenesis due to apoptosis during meiotic prophase I, defects in homologous chromosome synapsis, DNA damage, reduced DNA methylation, and derepression of L1 retrotransposons in the adult testis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
