| Primary Identifier | MGI:108409 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 19736 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable G-protein alpha-subunit binding activity; GTPase activator activity; and protein kinase binding activity. Predicted to be involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of transmembrane transport; and regulation of signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Is expressed in several structures, including eye; genitourinary system; gut; immune system; and nervous system. Orthologous to human RGS4 (regulator of G protein signaling 4). PHENOTYPE: Mice homozygous for one null allele display background dependent partially penetrant embryonic lethality, decreased body weight, and mildly impaired coordination. Another allele displays increased cholesterol levels in males. Mice homozygous for a different null allele exhibit no abnormal phenotype. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
