| Primary Identifier | MGI:1330808 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 15490 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables 3-keto sterol reductase activity; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity; and estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Involved in brain development; embryonic organ development; and steroid metabolic process. Acts upstream of or within several processes, including cholesterol biosynthetic process; embryonic skeletal system development; and nervous system development. Located in endoplasmic reticulum membrane. Is expressed in several structures, including autopod; extraembryonic component; eye; nervous system; and reproductive system. Orthologous to human HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7). PHENOTYPE: Mice homozygous for a targeted allele exhibit embryonic lethality, abnormal brain development, abnormal branchial arches, pericardial effusion, and abnormal cardiovascular development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
