| Primary Identifier | MGI:95496 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 14127 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables IgE receptor activity; identical protein binding activity; and immunoglobulin binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of interleukin-4 production; and serotonin secretion by platelet. Acts upstream of or within several processes, including immune response-regulating cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of immune effector process. Located in external side of plasma membrane. Part of Fc-epsilon receptor I complex. Is expressed in central nervous system; gut; male reproductive gland or organ; and retina. Orthologous to human FCER1G (Fc epsilon receptor Ig). PHENOTYPE: Homozygotes for targeted null mutations exhibit impairments in macrophage phagocytosis, NK cell-mediated antibody-coated cytotoxicity, mast cell degranulation, IgE-mediated systemic anaphylaxis, and neutrophil recruitment and migration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
