Primary Identifier | MGI:1339949 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 240913 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables metalloendopeptidase activity. Acts upstream of or within defense response to bacterium and proteolysis. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Orthologous to human ADAMTS4 (ADAM metallopeptidase with thrombospondin type 1 motif 4). PHENOTYPE: Homozygous mutant mice do not exhibit any morphological abnormalities. However, they do display impaired coordination and an increased susceptibility to pharmacologically induced seizures. [provided by MGI curators] |