| Primary Identifier | MGI:99542 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 22278 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including glucose mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter by glucose; and response to UV. Acts upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in Golgi apparatus; chromatin; and nucleoplasm. Predicted to be part of transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and tooth. Human ortholog(s) of this gene implicated in cardiovascular system disease and type 2 diabetes mellitus. Orthologous to human USF1 (upstream transcription factor 1). PHENOTYPE: Homozygous null mutants exhibit slight behavioral abnormalities. Females exhibit barbering and some have seizures. This knockout mutation (heterozygous or homozygous) acts as an enhancer of a null mutation of Usf2, resulting in embryonic lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
