| Primary Identifier | MGI:109294 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 18106 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable MHC class I protein binding activity. Involved in myeloid dendritic cell activation; natural killer cell activation involved in immune response; and positive regulation of lymphocyte proliferation. Located in external side of plasma membrane. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human CD244 (CD244 molecule). PHENOTYPE: Mice homozygous for a knock-out allele exhibit altered natural killer (NK) cell cytolysis. Mice homozygous for an ENU-generated allele exhibit reduced 'missing-self' targets recognition and elimination and increased clearance of B16 melanoma tumors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
