| Primary Identifier | MGI:104799 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 18611 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein kinase C binding activity. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of microtubule associated complex. Is expressed in several structures, including central nervous system; eye; future brain; and lung. Orthologous to human PEA15 (proliferation and apoptosis adaptor protein 15). PHENOTYPE: Homozygous null mice exhibit reduced body weight. Although Tnfa-induced apoptosis was increased in astrocytes in vitro, glial cell and brain morphology is normal. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
