| Primary Identifier | MGI:88512 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 12944 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including cholesterol binding activity; complement component C1q complex binding activity; and low-density lipoprotein particle binding activity. Predicted to be involved in several processes, including complement activation, classical pathway; regulation of biosynthetic process; and regulation of superoxide anion generation. Predicted to be located in filopodium and growth cone. Predicted to be active in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); macular degeneration (multiple); middle cerebral artery infarction; and nephritis (multiple). Orthologous to human CRP (C-reactive protein). PHENOTYPE: Mice homozygous for a knock-out allele lack detectable C-reactive protein in the serum but are otherwise healthy and fertile. Mice homozgyous for another null allele exhibit increased acetaminophen-induced liver injury and lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
