| Primary Identifier | MGI:1344367 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 23893 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables BMP binding activity; heparin binding activity; and identical protein binding activity. Involved in several processes, including determination of dorsal identity; embryonic body morphogenesis; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including central nervous system; chondrocranium; gut; integument; and lung. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human GREM2 (gremlin 2, DAN family BMP antagonist). PHENOTYPE: Mice homozygous for a null allele have malformed incisors but no bone defects. Homozygotes for a second null allele display excessive inflammation after myocardial infarction. Homozygotes for a third null allele show female subfertility, altered estrous cycles and low anti-Mullerian hormone levels. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
