Primary Identifier | MGI:2447076 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 269152 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ATP binding activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within establishment of cell polarity; positive regulation of cell-cell adhesion; and ureteric bud invasion. Predicted to be located in cytoplasm and microtubule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb interdigital region; and sensory organ. Orthologous to human KIF26B (kinesin family member 26B). PHENOTYPE: Mice homozygous for a knock-out allele exhibit neonatal lethality with impaired kidney development due to loss of cortical nephrogenic zone mesenchyme and failure of ureteric buds to invade and branch into the mesenchyme. [provided by MGI curators] |