Primary Identifier | MGI:1916976 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 69726 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II complex binding activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and histone H3K36 dimethyltransferase activity. Acts upstream of or within several processes, including cellular response to dexamethasone stimulus; nucleosome assembly; and regulation of protein phosphorylation. Located in nucleus. Is expressed in several structures, including cerebral cortex; early conceptus; gonad; hemolymphoid system gland; and liver. Orthologous to human SMYD3 (SET and MYND domain containing 3). PHENOTYPE: Mice homozygous for a null allele exhibit alleviated response to Ang II-induced vascular senescence. [provided by MGI curators] |