| Primary Identifier | MGI:1340806 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 11545 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables NAD+-protein ADP-ribosyltransferase activity and chromatin binding activity. Involved in several processes, including decidualization; negative regulation of adipose tissue development; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including DNA metabolic process; behavioral response to cocaine; and negative regulation of interleukin-17 production. Located in cytoplasm; nucleolus; and nucleoplasm. Part of protein-containing complex. Is active in chromatin; nucleus; and site of DNA damage. Is expressed in several structures, including brain; gonad; hemolymphoid system; intestine; and retina. Human ortholog(s) of this gene implicated in several diseases, including arthritis; bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). PHENOTYPE: Homozygous ablation of this gene may lead to skin hyperplasia, extreme sensitivity to radiation and alkylating agents, abnormal response to xenobiotics and endogenous compounds, reduced noise-induced hearing loss, altered susceptibility to neurotoxicity, or protection against renal ischemic injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
