Primary Identifier | MGI:2181366 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 170725 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium-dependent cysteine-type endopeptidase activity and identical protein binding activity. Acts upstream of or within calcium-dependent self proteolysis. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Is expressed in gut; liver; and male reproductive gland or organ. Orthologous to human CAPN8 (calpain 8). PHENOTYPE: Mice homozygous for a knock-out allele or allele that produces a proteolytically inactive protein exhibit increased sensitivity to ethanol-induced gastric mucosa injury. [provided by MGI curators] |