| Primary Identifier | MGI:1858171 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 53791 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable interleukin-1 receptor binding activity and pattern recognition receptor activity. Predicted to be involved in inflammatory response; pattern recognition receptor signaling pathway; and positive regulation of nitric oxide biosynthetic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; sensory organ; and trunk unsegmented mesenchyme. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5). PHENOTYPE: Mice homozygous for disruption of this gene have a generally normal phenotype. However they fail to respond immunologically to purified flagellin and are resistant to infection with Salmonella typhimurium. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
