| Primary Identifier | MGI:97838 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 107508 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables proline-tRNA ligase activity. Involved in several processes, including cellular response to insulin stimulus; cellular response to type II interferon; and prolyl-tRNA aminoacylation. Located in plasma membrane. Part of GAIT complex and aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; axial skeleton; cerebellum; cerebral cortex; and craniocervical region bone. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 15. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1). PHENOTYPE: Mice homozygous for a phospho-mimetic allele exhibit normal body weight, life span and glucose metabolism. Mice homozygous for a phospho-deficient allele exhibit decreased body weight, enhanced lipolysis, altered glucose metabolism and increased energy expenditure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
