| Primary Identifier | MGI:97772 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 19130 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including camera-type eye morphogenesis; circulatory system development; and positive regulation of cell differentiation. Acts upstream of or within several processes, including epithelial cell differentiation; hepatocyte cell migration; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; sensory organ; and skin. Used to study dilated cardiomyopathy and obesity. Orthologous to human PROX1 (prospero homeobox 1). PHENOTYPE: Homozygous mutation of this gene results in embryonic lethality with impaired development of the lens, lymphatic system, liver and pancreas. Heterozygous mutation results in early postnatal lethality with varying penetrance on different genetic backgrounds, obesity and lymphatic vessel abnormalities [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
