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Protein Coding Gene : Angel2 angel homolog 2
Primary Identifier  MGI:1196310 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  52477
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable mRNA 3'-UTR binding activity. Involved in mitochondrial mRNA 3'-end processing. Predicted to be located in Cajal body and cytoplasm. Orthologous to human ANGEL2 (angel homolog 2).
PHENOTYPE: Mice homozygous for a knock-out allele are viable and overtly normal but show a mild alteration of de novo translation in heart and liver mitochondria. Mitochondrial transcripts that undergo non-canonical RNA processing accumulate 3' phosphates, preventing their polyadenylation, causing a respiratory chain deficiency. [provided by MGI curators]
  • synonyms:
  • DNA segment, Chr 1, ERATO Doi 396, expressed,
  • DNA segment, Chr 1, ERATO Doi 654, expressed,
  • D1Ertd396e,
  • MGI:2138341,
  • MGI:1917712,
  • D1Ertd654e,
  • expressed sequence AI845692,
  • MGI:1917755,
  • angel homolog 2,
  • Angel2,
  • RIKEN cDNA 5730410O10 gene,
  • 2610307I21Rik,
  • AI845692,
  • MGI:1277170,
  • 5730410O10Rik,
  • RIKEN cDNA 2610307I21 gene
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