| Primary Identifier | MGI:1925491 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 381319 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in myeloid dendritic cell differentiation and response to virus. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in central nervous system and female associated reproductive structure. Orthologous to human BATF3 (basic leucine zipper ATF-like transcription factor 3). PHENOTYPE: Mice homozygous for a null mutation lack CD8alpha+ dendritic cells, have dysfunctional cross-presentation of antigens, and generate lower numbers of memory CD8+ T cells in response to infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
