Primary Identifier | MGI:1345281 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 22782 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium channel inhibitor activity. Involved in intracellular monoatomic cation homeostasis; negative regulation of monoatomic ion transport; and zinc ion transport. Acts upstream of or within in utero embryonic development. Predicted to be located in several cellular components, including T-tubule; basolateral plasma membrane; and postsynaptic density. Predicted to be active in several cellular components, including Golgi apparatus; Schaffer collateral - CA1 synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and nose. Orthologous to human SLC30A1 (solute carrier family 30 member 1). PHENOTYPE: Homozygous mutation of this gene results in embryonic lethality soon after implantation with embryonic growth arrest at the egg cylinder stage. Embryos from heterozygous females on a zinc deficient diet develop abnormally. [provided by MGI curators] |