| Primary Identifier | MGI:107684 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 18845 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables identical protein binding activity and semaphorin receptor activity. Involved in several processes, including chordate embryonic development; limb bud formation; and semaphorin-plexin signaling pathway. Acts upstream of or within cell surface receptor signaling pathway; centrosome localization; and cerebellar granule cell precursor tangential migration. Located in plasma membrane. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; heart; and peripheral nervous system. Orthologous to human PLXNA2 (plexin A2). PHENOTYPE: Mice homozygous for a knock-out allele show abnormal granule cell migration in the adult cerebellum and aberrant projection of mossy fibers in hippocampal slices. Mice homozygous for an ENU-induced allele are smaller and show granule cell migration defects and mild ataxia with incomplete penetrance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
