Primary Identifier | MGI:3045313 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 237256 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA endonuclease activity and mRNA binding activity. Involved in 3'-UTR-mediated mRNA destabilization. Acts upstream of or within mRNA catabolic process and negative regulation of T cell proliferation. Predicted to be located in P-body and nucleoplasm. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human ZC3H12D (zinc finger CCCH-type containing 12D). PHENOTYPE: Mice homozygous for a knock-out allele exhibit disrupted regulation of excessive inflammation. [provided by MGI curators] |