| Primary Identifier | MGI:2447810 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 353258 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in ribosomal small subunit biogenesis and ribosomal small subunit export from nucleus. Predicted to be located in nucleoplasm. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including cerebral cortex; limb digit; nose; oocyte; and skeleton. Human ortholog(s) of this gene implicated in inflammatory poikiloderma with hair abnormalities and acral keratoses. Orthologous to human LTV1 (LTV1 ribosome biogenesis factor). PHENOTYPE: Mice homozygous for a knock-out allele show embryonic lethality before implantation. In vitro outgrowth assays show that morula-like embryos fail to hatch from the zona pellucida and do not form blastocysts. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
