Primary Identifier | MGI:106387 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 215821 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to be located in transport vesicle membrane. Is expressed in central nervous system; dorsal root ganglion; and sensory organ. Orthologous to human ARFGEF3 (ARFGEF family member 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased insulin granule biogenesis and insulin secretion. [provided by MGI curators] |