| Primary Identifier | MGI:1929938 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 64058 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in mammary gland duct morphogenesis; positive regulation of T cell apoptotic process; and tissue homeostasis. Acts upstream of or within several processes, including amelogenesis; desmosome organization; and intrinsic apoptotic signaling pathway by p53 class mediator. Located in several cellular components, including Golgi apparatus; desmosome; and mitochondrion. Is expressed in several structures, including alimentary system; brain ventricle and choroid plexus; limb primordium; sensory organ; and skin. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Orthologous to human PERP (p53 apoptosis effector related to PMP22). PHENOTYPE: Homozygous inactivation of this locus results in increased lethality during the postnatal period. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
