Primary Identifier | MGI:2665114 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 237310 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable interleukin-22 binding activity and interleukin-22 receptor activity. Acts upstream of or within negative regulation of inflammatory response and regulation of tyrosine phosphorylation of STAT protein. Located in cytosol. Orthologous to human IL22RA2 (interleukin 22 receptor subunit alpha 2). PHENOTYPE: Mice homozygous for a null mutation display accelerated tumor formation in a colitis associated colon cancer model. [provided by MGI curators] |