| Primary Identifier | MGI:1340062 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 20393 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein kinase activity. Acts upstream of or within DNA damage response; cellular response to aldosterone; and protein phosphorylation. Predicted to be located in cytosol; nuclear speck; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; cardiovascular system; eye; limb interdigital region mesenchyme; and respiratory system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1). PHENOTYPE: Homozygous knockout results in reduced sensitivity to hypoxia-induced pulmonary arterial hypertension, inflammation and cardiac ventricular hypertrophy. But otherwise mice display an essentially normal phenotype. Sodium retention is compromised on a low salt diet. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
