| Primary Identifier | MGI:2443552 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 210757 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in T cell receptor signaling pathway; negative T cell selection; and positive T cell selection. Located in cell-cell junction; cytoplasm; and nucleus. Part of COP9 signalosome. Is expressed in lymph node; spleen; and thymus. Orthologous to human THEMIS (thymocyte selection associated). PHENOTYPE: Homozygous null mice have defects in T cell positive selection that leads to very few alpha-beta T cells being found in the periphery. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
