| Primary Identifier | MGI:1915281 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 68031 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable enzyme binding activity; poly-ADP-D-ribose binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including cellular response to hydrogen peroxide; positive regulation of canonical Wnt signaling pathway; and protein ubiquitination. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system and genitourinary system. Used to study osteochondrodysplasia. Orthologous to human RNF146 (ring finger protein 146). PHENOTYPE: Mice homozygous for a conditional allele activated in immune cells exhibit osteopenia with enhanced osteoclastogenesis. Mice homozygous for a conditional allele activated in osteoblast exhibit ostepenia with impaired osteoblast numbers, increased adipogenesis and impaired glucose tolerance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
