| Primary Identifier | MGI:1890563 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 83767 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Predicted to contribute to small GTPase binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; dendrite extension; and modification of postsynaptic actin cytoskeleton. Acts upstream of or within lamellipodium morphogenesis. Located in lamellipodium and mitochondrial outer membrane. Is active in postsynapse. Is expressed in several structures, including central nervous system; liver; spleen; testis; and tooth. Orthologous to human WASF1 (WASP family member 1). PHENOTYPE: Mutation of this gene has been associated with both morphological and functional defects of the central nervous system. Targeted mutagenesis has resulted in mice that display sensorimotor and cognitive defects similar to those exhibited by patients with 3p-syndrome mental retardation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
