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Protein Coding Gene : Prep prolyl endopeptidase
Primary Identifier  MGI:1270863 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  19072
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables metallocarboxypeptidase activity. Involved in angiotensin maturation. Located in cytoplasm and nucleus. Is active in extracellular region. Is expressed in several structures, including cranial ganglion; genitourinary system; heart ventricle; thymus primordium; and vibrissa. Orthologous to human PREP (prolyl endopeptidase).
PHENOTYPE: Mice homozygous for a gene trap allele exhibit sex-dependent resistance to diet-induced obesity and adiposity. Mice heterozygous for a gene trap allele exhibit maternal inheritance influenced increase in body weight, organ weight, and adiposity. [provided by MGI curators]
  • synonyms:
  • expressed sequence AI450383,
  • D10Wsu136e,
  • AI450383,
  • Pop,
  • expressed sequence AI047692,
  • prolyl oligopeptidase,
  • MGI:2143608,
  • MGI:2143520,
  • AI047692,
  • Prep,
  • prolyl endopeptidase,
  • MGD-MRK-35736,
  • DNA segment, Chr 10, Wayne State University 136, expressed,
  • MGI:107271
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Features --> Cross References

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2 Involved In Mutations

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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