| Primary Identifier | MGI:97999 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 19886 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein phosphatase binding activity and protein tyrosine kinase activity. Involved in several processes, including columnar/cuboidal epithelial cell development; peptidyl-tyrosine autophosphorylation; and regulation of ERK1 and ERK2 cascade. Acts upstream of or within several processes, including negative regulation of gene expression; regulation of phosphate transport; and signal transduction. Located in cell surface and perinuclear region of cytoplasm. Is expressed in several structures, including genitourinary system; intestine; lung; stomach; and trunk. Orthologous to human ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase). PHENOTYPE: Homozygotes for targeted null mutations exhibit male infertility due to impaired sperm maturation in the epididymis. Mutant sperm are capable of fertilization in vitro but not in vivo. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
