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Protein Coding Gene : Pla2g12b phospholipase A2, group XIIB
Primary Identifier  MGI:1917086 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  69836
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable calcium ion binding activity and phospholipase A2 activity. Acts upstream of or within cholesterol homeostasis; low-density lipoprotein particle remodeling; and triglyceride homeostasis. Predicted to be located in extracellular region. Is expressed in alimentary system; liver; liver lobe; and yolk sac endoderm. Orthologous to human PLA2G12B (phospholipase A2 group XIIB).
PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit a reduction in serum total and HDL cholesterol levels, decreased serum triglyceride levels, and hepatic steatosis. [provided by MGI curators]
  • synonyms:
  • heart, lung and blood, 218,
  • MGI:2678708,
  • hlb218,
  • 2010002E04Rik,
  • phospholipase A2, group XIII,
  • Pla2g12b,
  • Pla2g13,
  • RIKEN cDNA 2010002E04 gene,
  • phospholipase A2, group XIIB
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2 Involved In Mutations

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Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

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