| Primary Identifier | MGI:3026965 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 215999 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables calcium channel activity. Involved in calcium import into the mitochondrion; positive regulation of apoptotic process; and positive regulation of mitochondrial calcium ion concentration. Acts upstream of or within cell migration; cell population proliferation; and generation of precursor metabolites and energy. Located in mitochondrion. Part of calcium channel complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and limb segment. Orthologous to human MCU (mitochondrial calcium uniporter). PHENOTYPE: Mice homozygous for a gene trap allele exhibit impaired calcium-induced permeability transition pore opening, decreased body size and weight, decreased exercise endurance and decreased grip strength. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
