| Primary Identifier | MGI:1858224 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 53374 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chondroitin 6-sulfotransferase activity and proteoglycan sulfotransferase activity. Involved in chondroitin sulfate biosynthetic process. Acts upstream of or within T cell homeostasis. Is active in Golgi apparatus. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and respiratory system. Used to study schizophrenia. Human ortholog(s) of this gene implicated in osteochondrodysplasia and spondyloepiphyseal dysplasia with congenital joint dislocations. Orthologous to human CHST3 (carbohydrate sulfotransferase 3). PHENOTYPE: Homozygous mutation of this gene results in significantly reduced numbers of naive T lymphocytes in the spleen at 5-6 weeks of age. Brain development and morphology is normal in mutant animals but for some alleles behavioral abnormalities are seen. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
