Primary Identifier | MGI:2179942 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 237360 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables peptidase activity. Acts upstream of or within collagen fibril organization. Located in extracellular region. Is expressed in vertebral axis musculature. Human ortholog(s) of this gene implicated in osteoarthritis; primary progressive multiple sclerosis; and relapsing-remitting multiple sclerosis. Orthologous to human ADAMTS14 (ADAM metallopeptidase with thrombospondin type 1 motif 14). PHENOTYPE: Mice homozygous for a knock-out allele are viable, healthy and fertile and exhibit normal aminoprocollagen processing. [provided by MGI curators] |