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Protein Coding Gene : Aifm2 apoptosis-inducing factor, mitochondrion-associated 2
Primary Identifier  MGI:1918611 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  71361
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable several functions, including electron-transferring-flavoprotein dehydrogenase activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Involved in regulation of cellular response to oxidative stress. Located in mitochondrial membrane and nucleus. Is expressed in adrenal medulla; central nervous system; and retina. Orthologous to human AIFM2 (AIF family member 2).
PHENOTYPE: Homozygous null mice display reduced sensitivity to genotoxin induced cellular growth inhibition but have no change in spontaneous or induced tumor incidence. [provided by MGI curators]
  • synonyms:
  • PRG3,
  • MGI:1926110,
  • D730001I10Rik,
  • apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death,
  • 5430437E11Rik,
  • Amid,
  • RIKEN cDNA 5430437E11 gene,
  • apoptosis-inducing factor, mitochondrion-associated 2,
  • RIKEN cDNA D730001I10 gene,
  • Aifm2
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