| Primary Identifier | MGI:1355553 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 53404 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables transcription cis-regulatory region binding activity. Involved in several processes, including entrainment of circadian clock by photoperiod; positive regulation of retinal ganglion cell axon guidance; and response to auditory stimulus. Acts upstream of or within circadian rhythm; entrainment of circadian clock; and neural retina development. Located in axon; nucleus; and perikaryon. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in persistent hyperplastic primary vitreous. Orthologous to human ATOH7 (atonal bHLH transcription factor 7). PHENOTYPE: Homozygous mutation of this gene results in impaired differentiation of retinal ganglion cells resulting in an increase of amacrine cells. Mice show impaired optic nerve formation and one allele shows loss of circadian photoentrainment. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
